virtual seminars it couldn't be easier
Exploring the Applications of RNA Interference (RNAi) Technologies |
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Registration for the live event is now closed. However, if you are interested in viewing an online recording which contains the entire presentation, including audio, you may purchase this for $169 USD. Please click the button below and you will be emailed information on how to access the recorded event. MAC USERS: Unfortunately at this time the recordings cannot be viewed on the MAC OS. This online real-time presentation focused on the applications of siRNA to identify and inhibit clinically relevant RNA targets. Emphasis will be placed on challenges involved in development of siRNAs as viable therapeutic agents in both systemic and local delivery settings. Most eukaryotic cells contain an intracellular defense system against invasion from outside agents and aberrant expression of endogenous genetic elements. This defense system is triggered by agent-specific double-stranded RNA, which is engaged by an RNAseIII-like nuclease called Dicer. Dicer processes dsRNA into short duplexes of 21-25 nucleotides in length. These short duplexes are recognized by a large protein complex called RISC, RNAi induced silencing complex. The RISC complex is activated in the presence of ATP and becomes capable of specific mRNA recognition guided by the sequence of one of strands of the short duplex RNA. The target mRNA is endonucleolytically cleaved leading to inhibition of expression at the translational level. Although the precise biochemical details remain to be worked out, the process of RNA interference (RNAi) mediated by short dsRNA (siRNA) has already proven to be of immense value in gene silencing in cell culture. Efforts are underway to extend the utility of siRNA into in vivo settings as a highly specific yet broadly applicable mechanism for gene silencing. These efforts require chemical modifications to stabilize siRNA against nucleolytic degradation and mechanisms to optimize pharmacokinetic performance and delivery to the target organ. Be Sure to Participate in this Virtual Seminar. You will be able to "attend" this real-time tutorial from anywhere that you have an internet connection.from your office or from your conference room. One Low Registration Fee entitled you to a “site” registration, which enables you to invite your colleagues and members of your staff to participate, whether gathered around a computer or in a conference room with speakerphone and screen. It Couldn’t Be Easier! You’ll view the presentation over your web browser. On a separate telephone line (which you can put on speakerphone), you will hear the audio and be able to ask questions of the presenter. You can also submit questions from your keyboard. Time Well Spent! No travel, no time away. From your office or conference room, this hour-and-a-half seminar will provide you with an authoritative presentation that includes ample time for your questions and discussion. Registrations will be limited to ensure interactive participation. The 1½–hour presentation will:
Presented by Genetic Engineering News |
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