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Protein Profiling: Quantitative Mass Spectrometry for Expression Analysis

Speaker:
Christopher Colangelo, Ph.D.
Director of Protein Profiling
W.M. Keck Foundation Biotechnology Resource Laboratory
Yale University

Moderated by:
Jennifer Krone, Ph.D.
Senior Field Application Specialist–Proteomics
Applied Biosystems

Registration for the live event is now closed. However, if you are interested in viewing an online recording which contains the entire presentation, including audio, you may purchase this for $169 USD. Please click the button below and you will be emailed information on how to access the recorded event. MAC USERS: Unfortunately at this time the recordings cannot be viewed on the MAC OS.

Providing an overview of the newest data and technologies relating to the expression and characterization of proteins for biological understanding and therapeutics.

One of the most fundamental approaches to understanding protein function is to correlate expression-level changes as a function of growth conditions, cell-cycle stage, disease state, external stimuli, level of expression of other proteins, or other variables. Although DNA microarray analysis offers a massively parallel approach to genome-wide mRNA expression analysis, there often is not a direct relationship between in vivo concentration of mRNA and encoded protein.

Differential rates of translation of mRNAs into protein and of protein degradation in vivo are but two factors confounding the extrapolation of mRNA to protein expression profiles. Recent research, to be presented, shows that protein concentration can vary by >100-fold for a given mRNA concentration. In addition, microarray analysis cannot detect, identify, or quantify posttranslational protein modifications—key modulators of protein function. In measuring the level of the biological effector protein molecule, not just that of a protein’s message, protein expression analysis stands to advance significantly the contribution of proteomics to the development of novel therapeutics.

The 1½–hour presentation will address:

  • Basic review of mass spectrometry applications to proteomics
  • Correlating protein expression-patterns from DNA microarray and mass spectrometry
  • Mass spectrometry biomarker profiling for monitoring cellular changes associated with disease states and external influences
  • Overview of mass spectrometric tools for functional proteomics
  • Advances toward quantitative, comprehensive characterization of cellular components and associated activity in a given biological system

An extensive Q&A session, with worldwide participation followed.

Participate in this Virtual Seminar. You can attend this real-time tutorial from anywhere you have an Internet connection.

One Low Registration Fee of $149 entitled you to a site registration, which enables you and unlimited additional colleagues and staff to participate, whether gathered around a computer or in a conference room with speakerphone and screen.

It Couldn’t Be Easier! You’ll view the presentation over your Web browser. On a separate telephone line (which can be put on speakerphone), you will hear the audio and be able to ask questions of the presenter and moderator. You can also submit questions by your keyboard.

Time Well Spent! No travel, no time away. GEN’s hour-and-a-half virtual seminars are authoritative presentations by industry leaders that include ample time for questions and discussion. Registrations will be limited to ensure interactive participation.

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